![]() Cellular senescence is a phenotype characterized by cell cycle arrest, senescence-associated β-galactosidase (SA-β-gal), and a hypermetabolic state. Our laboratory has demonstrated both in vitro and in vivo that cellular senescence occurs in a subset of these cells. The response of cancer cells to ADT includes apoptosis and cell death, but a significant fraction remains viable. ![]() The mechanisms surrounding this improved cancer outcomes are incompletely defined. Recent clinical trials have demonstrated that ADT combined with other agents, notably docetaxel and abiraterone, lead to improved survival. However, this approach is rarely curative. Androgen deprivation therapy (ADT) has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer (PCa).
0 Comments
Leave a Reply. |